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| Status |
Public on Dec 01, 2018 |
| Title |
Transcriptome analysis identifies the dysregulation of ultraviolet target genes in human skin cancers |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we performed RNA-Seq studies to generate a transcriptomic cohort containing UV-responsive genes in human skin cells exposed to different UVR conditions. We then performed rigorous bioinformatics analysis to define a UV gene expression signature that is conserved among cells from different donors. We further demonstrated that the UV signature genes are significantly enriched in genes dysregulated in human skin squamous cell carcinomas.
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| Overall design |
UV-responsive genes were identified by characterzing the differentially expressed genes between UV-irradiated human keratinocytes and non-irradiated control keratinocytes.
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| Contributor(s) |
Shen Y, Liu L |
| Citation(s) |
27643989 |
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| Submission date |
Aug 10, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Liang Liu |
| Organization name |
Columbia University
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| Street address |
1150 St. Nicholas Avenue
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (24)
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| GSM2267053 |
N0, UV, 4h/30 (time/dose) vs. control |
| GSM2267054 |
N0, UV, 1d/10 (time/dose) vs. control |
| GSM2267055 |
N0, UV, 1d/20 (time/dose) vs. control |
| GSM2267056 |
N0, UV, 1d/30 (time/dose) vs. control |
| GSM2267057 |
N0, UV, 3d/10 (time/dose) vs. control |
| GSM2267058 |
N0, UV, 3d/20 (time/dose) vs. control |
| GSM2267059 |
N0, UV, 3d/30 (time/dose) vs. control |
| GSM2267060 |
N1 control |
| GSM2267061 |
N1, UV, 1d/10 (time/dose) vs. control |
| GSM2267062 |
N1, UV, 1d/20 (time/dose) vs. control |
| GSM2267063 |
N1, UV, 1d/30 (time/dose) vs. control |
| GSM2267064 |
N1, UV, 3d/10 (time/dose) vs. control |
| GSM2267065 |
N1, UV, 3d/20 (time/dose) vs. control |
| GSM2267066 |
N1, UV, 3d/30 (time/dose) vs. control |
| GSM2267067 |
N2 control |
| GSM2267068 |
N2, UV, 1d/10 (time/dose) vs. control |
| GSM2267069 |
N2, UV, 1d/20 (time/dose) vs. control |
| GSM2267070 |
N2, UV, 1d/30 (time/dose) vs. control |
| GSM2267071 |
N2, UV, 3d/10 (time/dose) vs. control |
| GSM2267072 |
N2, UV, 3d/20 (time/dose) vs. control |
| GSM2267073 |
N2, UV, 3d/30 (time/dose) vs. control |
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| Relations |
| BioProject |
PRJNA338465 |
| SRA |
SRP081236 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE85443_RAW.tar |
13.9 Mb |
(http)(custom) |
TAR (of CSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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