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| Status |
Public on Jun 30, 2017 |
| Title |
A multi-scale model for hair follicle reveals heterogeneous skin domains drive rapid spatiotemporal hair growth patterning |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report transcriptomes of whole skin from different anatomic regions, dorsum, ventrum, chin and ear pinna, as well as ear cartilage/muscle complex at different post-natal time points. Whole tissue was microdissected from wild type mice.
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| Overall design |
Examination of miscrodissected whole skin from dorsum, ventrum and chin at six consecutive time points of the hair cycle, and comparison of ear pinna telogen skin vs. ear cartilage/muscle complex vs. dorsal telogen skin.
Sample definition:
CCT Chin skin, Competent telogen
CEA Chin skin, Early anagen
CMA Chin skin, Mid-anagen
CLA Chin skin, Late anagen
CC Chin skin, Catagen
CRT Chin skin, Refractory telogen
VCT Ventral skin, Competent telogen
VEA Ventral skin, Early anagen
VMA Ventral skin, Mid-anagen
VLA Ventral skin, Late anagen
VC Ventral skin, Catagen
VRT Ventral skin, Refractory telogen
DCT Dorsal skin, Competent telogen
DEA Dorsal skin, Early anagen
DMA Dorsal skin, Mid-anagen
DLA Dorsal skin, Late anagen
DC Dorsal skin, Catagen
DRT Dorsal skin, Refractory telogen
ERST Ear skin, Telogen
LC Ear cartilage/muscle complex
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| Contributor(s) |
Plikus MV, Nie Q, Oh J, Wang Q, Lee H, Peng T |
| Citation(s) |
28695824 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 AR067273 |
Induction of fat regeneration in skin wounds by hair follicle signaling |
The Regents of the University of California |
Plikus |
| P50 GM076516 |
Develop new mathematical and computational tools for modeling: Math & Computational Core |
The Regents of the University of California |
Nie |
| R01 GM107264 |
Stochastic Dynamics and Noise Control in Patterning Systems |
The Regents of the University of California |
Nie |
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| Submission date |
Aug 01, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Maksim V Plikus |
| E-mail(s) |
plikus@uci.edu
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| Phone |
949-824-1260
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| Organization name |
University of California, Irvine
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| Department |
Developmental and Cell Biology
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| Street address |
845 Health Sciences Road
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| City |
Irvine |
| State/province |
California |
| ZIP/Postal code |
92697 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA336009 |
| SRA |
SRP080746 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE85039_Ear_pinna_RNAseq_fpkm.txt.gz |
707.7 Kb |
(ftp)(http) |
TXT |
| GSE85039_Skin_domains_RNAseq_fpkm.txt.gz |
2.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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