|
| Status |
Public on Dec 12, 2016 |
| Title |
Integrated analyses identify phenotype specific BMP4 signaling in breast cancer [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Bone morphogenetic protein 4 (BMP4) plays an important role in cancer pathogenesis. In breast cancer, it reduces proliferation and increases migration in a cell line-dependent manner. To characterize the transcriptional mediators of these phenotypes, we performed RNA-seq and DNase-seq analyses after BMP4 treatment in MDA-MB-231 and T-47D breast cancer cells that respond to BMP4 with enhanced migration and decreased cell growth, respectively.
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| |
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| Overall design |
We characterized mRNA levels from BMP4 treated and non-treated MDA-MB-231 and T-47D cells using RNA-seq
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| |
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| Contributor(s) |
Ampuja M, Rantapero T, RodrÃquez-Martinez A, Palmroth M, Alarmo E, Nykter M, Kallioniemi A |
| Citation(s) |
28077088 |
| |
| Submission date |
Jul 19, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Tommi Tapani Rantapero |
| E-mail(s) |
tommi.rantapero@staff.uta.fi
|
| Organization name |
University of Tampere
|
| Department |
BioMediTech
|
| Street address |
Biokatu 8
|
| City |
Tampere |
| ZIP/Postal code |
33520 |
| Country |
Finland |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE84579 |
Integrated analyses identify phenotype specific BMP4 signaling in breast cancer |
|
| Relations |
| BioProject |
PRJNA329672 |
| SRA |
SRP078931 |
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