|
| Status |
Public on Jun 12, 2019 |
| Title |
Transcriptomic profile of circulating memory T cells can differentiate between latent tuberculosis individuals and healthy controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Tuberculosis (TB) is responsible for the majority of mortality and morbidity associated with infectious diseases worldwide. The characterization of exact molecular components of immune response associated with protection against TB may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of memory T cells associated with latent infection with Mycobacterium tuberculosis. Transcriptomic profiling using RNA sequencing was performed on memory CD4 and CD8 T cells isolated from individuals with latent tuberculosis, as well as from tuberculosis negative healthy controls. Overall, we found specific gene signatures in each cell subset that could successfully discriminate between individuals with latent tuberculosis and healthy controls.
|
| |
|
| Overall design |
RNA-sequencing of sorted memory CD4 and CD8 T cells from cryopreserved PBMC of 10 subjects with latent tuberculosis infection and 10 tuberculosis negative healthy controls
|
| |
|
| Contributor(s) |
Burel J, Lindenstam C, Seumois G, Fu Z, Greenbaum J, Sette A, Peters B, Vijayanand P |
| Citation(s) |
29602771, 31237234 |
| |
| Submission date |
Jul 15, 2016 |
| Last update date |
Jul 01, 2019 |
| Contact name |
Bjoern Peters |
| E-mail(s) |
bpeters@lji.org
|
| Organization name |
La Jolla Institute for Immunology
|
| Street address |
9420 Athena Cir
|
| City |
La Jolla |
| State/province |
California |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (40)
|
|
| Relations |
| BioProject |
PRJNA329186 |
| SRA |
SRP078560 |
Less...
More...