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| Status |
Public on Jan 15, 2017 |
| Title |
IFN-γ and IL-4 regulate epigenetic modifiers in macrophages |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Interferon-γ (IFN-γ) or interleukin-4 (IL-4) prime macrophages towards classical (M1) or alternative (M2) activation, respectively. How IFN-γ and IL-4 prime epigenetic responses by altering expression of histone modifying enzymes and how this affects M1/M2 polarization is incompletely understood.
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| Overall design |
We performed a microarray study of transcripts upregulated by IFN-γ or IL-4 in the presence and absence of the combined KDM6A and B inhibitor GSK-J4
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| Contributor(s) |
Yıldırım-Buharalıoğlu G, Bond M, Sala-Newby GB, Hindmarch CC, Newby AC |
| Citation missing |
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| |
| Submission date |
Jul 01, 2016 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Andrew Newby |
| E-mail(s) |
chipboy101@gmail.com
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| Organization name |
University of Bristol
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| Street address |
Level 7 Bristol Royal Infirmary, Upper Maudlin Street
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| City |
Bristol |
| State/province |
International/Other |
| ZIP/Postal code |
BS2 8HW |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA327558 |
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