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| Status |
Public on Aug 08, 2016 |
| Title |
Epigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report mapping of the PAX8 cistrome in three high grade serous ovarian cancer cell lines (KURAMOCHI, OVSAHO, and JHOS4) compared to three benign immortalized fallopian tube cell lines (FT33, FT194, and FT246). We identified a highly conserved PAX8 binding pattern common across benign fallopian tube cell lines that was distinct from the unique PAX8 binding patterns seen in each cancer cell line.
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| Overall design |
Comparison of benign and malignant Mullerian cell lines with and without PAX8 knockdown. For each cell line, three distinct siRNAs targeting PAX8 plus a pool of all three siRNAs were examined and compared to both a non-transfected control as well as a control transfected with a non-targeting siRNA.
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| |
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| Contributor(s) |
Elias K |
| Citation(s) |
27617304, 34771603 |
| |
| Submission date |
Jun 08, 2016 |
| Last update date |
Feb 08, 2022 |
| Contact name |
Kevin Meyer Elias |
| E-mail(s) |
kelias1@partners.org
|
| Phone |
617-732-8840
|
| Organization name |
Brigham and Women's Hospital
|
| Department |
OB/GYN
|
| Lab |
Gynecologic Oncology
|
| Street address |
75 Francis Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (34)
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| This SubSeries is part of SuperSeries: |
| GSE83101 |
Epigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer |
|
| Relations |
| BioProject |
PRJNA324760 |
| SRA |
SRP076260 |
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