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| Status |
Public on May 17, 2017 |
| Title |
RNA-seq analysis of primary patient samples to characterize the CNS leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We present a detailed genetic, transcriptional and physiological study of leukemic cells isolated from the CNS and bone marrows (BM) of both affected children and xenograft model of B-ALL which recapitulate the key features of CNS involvement. We reveal that leukemic cells in CNS possess distinct hypoxic signature such as proliferation suppression, decrease of mitochondrial oxidative phosphorylation and increase of glycolysis compared with leukemic cells in BM.
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| |
|
| Overall design |
We compared the gene expression profiles of leukemic cells isolated from CSF and BM of primary 3 patients (ALL#6-8) with RNA-seq.
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| |
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| Contributor(s) |
Kato I, Ozawa H, Wang D, Nakamura M, Watanabe A |
| Citation(s) |
28424164 |
| |
| Submission date |
May 17, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Akira Watanabe |
| E-mail(s) |
a.watanabe@cyberomix.com
|
| Organization name |
CyberomiX Inc
|
| Street address |
Rm504, Miyako Bldg, 233, Isa-cho, kamigyo-ku
|
| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
602-8407 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE81519 |
Transcriptome analysis of CNS leukemia |
|
| Relations |
| BioProject |
PRJNA321847 |
| SRA |
SRP075273 |
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