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| Status |
Public on May 06, 2017 |
| Title |
RNA-seq analysis of Kdm6a deficient brains in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Kdm6a is an X-linked histone demethylase that activates gene expression via removal of the repressive methylation mark at histone H3 lysine 27 (H3K27). In humans, KDM6A mutations cause Kabuki syndrome, a disorder characterized by intellectual disability and motor coordination deficits. To assess the role of Kdm6a in brain development and behavior, we generated a neuron-specific Kdm6a deficient mouse model using Cre-LoxP recombination. The mutant mice exhibited an adult-onset deficit in motor coordination. We then performed RNA-seq analysis to determine the mis-regulated genes that are listed in this dataset.
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| |
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| Overall design |
Genome-wide gene expression was determined in the brain between 3 adult male Kdm6a deficient and 3 wild type littermate mice.
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| Contributor(s) |
Xu J, Li R |
| Citation missing |
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| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 MH096066 |
Novel epigenetic mechanisms in neuronal development and cognitive function |
CHILDREN'S HOSPITAL |
XU |
|
| |
| Submission date |
May 09, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Rui Li |
| Organization name |
University of Massachusetts Medical School
|
| Department |
MCCB
|
| Street address |
364 Plantation Street, LRB
|
| City |
Worcester |
| State/province |
Massachusetts |
| ZIP/Postal code |
01605 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA321062 |
| SRA |
SRP074611 |
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