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| Status |
Public on Dec 15, 2017 |
| Title |
FOXO1 is an oncogenic mediator in AML1-ETO leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Transcriptome analysis by RNAseq of human CD34+ hematopoietic stem and progenitor cells transduced with empty vector control(MIT), AML1-ETO (AE), wildtype FOXO1 (F WT) or FOXO1 DNA binding deficient mutant (F DB). We find wildtype FOXO1 partially recapitulates gene signature of AML1-ETO
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| Overall design |
Human CD34+ hematopoietic stem and progenitor cells from three donors were transduced with retrovirus expressing MIT, AE, F WT or F DB. Transduced cells were sorted at day 5 after transduction, RNA was collected for RNAseq.
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| Contributor(s) |
Lin S, Mulloy JC |
| Citation missing |
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| |
| Submission date |
May 04, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Shan Lin |
| Organization name |
Cincinnati Children's Hospital Medical Center
|
| Department |
EHCB
|
| Lab |
James Mulloy
|
| Street address |
3333 Burnet Avenue, CCHMC
|
| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL15433 |
Illumina HiSeq 1000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA320467 |
| SRA |
SRP074342 |
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