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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 23, 2016 |
| Title |
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on neoplastic cell-autonomous processes for these adaptations. We demonstrate that exosomes secreted by patient-derived CAFs can strikingly reprogram the metabolic machinery following their uptake by cancer cells.
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| Overall design |
Total RNA obtained from purified exosomes from patient derived CAFs
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| Contributor(s) |
Zhao H, Yang L, Baddour J, Achreja A, Bernard V, Moss T, Marini JC, Tudawe T, Seviour EG, San Lucas FA, Alvarez H, Gupta S, Maiti SN, Cooper L, Peehl D, Ram PT, Maitra A, Nagrath D |
| Citation(s) |
26920219 |
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| Submission date |
Apr 22, 2016 |
| Last update date |
Sep 29, 2017 |
| Contact name |
Prahlad T. Ram |
| Organization name |
University of Texas MD Anderson Cancer Center
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| Department |
Systems Biology
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| Street address |
7435 Fannin St.
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77054 |
| Country |
USA |
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| Platforms (1) |
| GPL19223 |
NanoString nCounter Human miRNA Expression Assay v2 [miRBase accession version] |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA319375 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE80586_raw.txt.gz |
9.5 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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