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Status |
Public on Feb 28, 2008 |
Title |
FLT3 gene-expression signature in normal karyotype AML |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Acute myeloid leukemia with normal karyotype (NK-AML) represents a cytogenetic grouping with intermediate prognosis but substantial molecular and clinical heterogeneity. Within this subgroup, presence of FLT3 (FMS-like tyrosine kinase 3) internal tandem duplication (ITD) mutation predicts less favorable outcome. The goal of our study was to discover gene-expression patterns correlated with FLT3-ITD mutation, and to evaluate the utility of a FLT3 signature for prognostication. The dataset comprises gene-expression profiles of 137 normal karyotype acute myeloid leukemia (NK-AML) specimens carried out using Stanford cDNA microarrays, to accompany the study of L Bullinger et al. For each array, Channel 2 represents Cy5-labeled NK-AML RNA, and Channel 1 Cy3-labeled universal reference RNA. Keywords: Logical Set
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Overall design |
DNA microarrays were used to profile gene expression in a training set of 65 NK-AML cases. Supervised analysis was applied to build a gene expression-based predictor of FLT3-ITD mutation status. The predictor was then evaluated by classifying expression profiles from an independent test set of 72 NK-AML cases.
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Contributor(s) |
Bullinger L |
Citation(s) |
18309032 |
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Submission date |
Jun 06, 2007 |
Last update date |
Mar 17, 2012 |
Contact name |
Jonathan Pollack |
E-mail(s) |
pollack1@stanford.edu
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Phone |
650-736-1987
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Organization name |
Stanford University
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Department |
Pathology
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Lab |
Pollack Lab
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Street address |
269 Campus Drive, CCSR3245A
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City |
Stanford |
State/province |
CA |
ZIP/Postal code |
94305-5176 |
Country |
USA |
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Platforms (8)
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Samples (137)
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GSM198462 |
99PB940, 46,XX |
GSM198463 |
98PB944, 46,XY |
GSM198464 |
02PB786, normal |
GSM198465 |
02PB2243, normal |
GSM198466 |
02KM2278, normal |
GSM198467 |
02PB1568, normal |
GSM198468 |
02KM1932, normal |
GSM198469 |
03PB1447, 46,XY in Kiel |
GSM198470 |
03KM1554, 46,XY [17] |
GSM198471 |
03KM1676, 46,XX[14] |
GSM198472 |
03KM1094, 46,XY[12] |
GSM198473 |
02KM883, normal |
GSM198474 |
02PB2565, normal |
GSM198475 |
AML 102 |
GSM198476 |
01PB2625, normal |
GSM198477 |
01PB2622, normal |
GSM198478 |
03KM104, 46,XX[10] |
GSM198479 |
98KM1477, 46,XX |
GSM198480 |
01KM3019, normal |
GSM198481 |
98KM1558, 46,XY |
GSM198482 |
03KM273, 46,XX[12] |
GSM198483 |
02PB2479, 46,XX[15] |
GSM198484 |
01KM2574, 46,XY |
GSM198485 |
03PB1812, 46,XX[13] |
GSM198486 |
02PB492, 46,XX[16] |
GSM198487 |
02PB1577, 46,XY[20] in Kiel |
GSM198488 |
02PB1826, 46,XY[9] |
GSM198489 |
03KM1689, 46,XX[5] |
GSM198490 |
03KM1761, 46,XX[11] |
GSM198491 |
03KM2434, 46,XX[10] |
GSM198492 |
01KM2453, 46,XX[20], keine Metaph. |
GSM198493 |
03KM3230, 46,XX[12] |
GSM198494 |
02KM114, 46,XY[15] |
GSM198495 |
00PB1872, 46,XX[12] |
GSM198497 |
01KM1521, 46,XX[13] |
GSM198498 |
01KM486, normal |
GSM198499 |
AML 113 |
GSM198500 |
99KM1241, normal |
GSM198501 |
01KM3062, normal |
GSM198502 |
99PB1458, normal |
GSM198503 |
00PB7, normal |
GSM198504 |
02KM4, normal |
GSM198505 |
00KM184, normal |
GSM198506 |
00KM331, normal |
GSM198507 |
02KM494, 46,XX[10] |
GSM198508 |
03KM2531, 46,XX[13] |
GSM198509 |
00KM468, 46,XX |
GSM198511 |
00KM2221, normal |
GSM198512 |
AML 9 |
GSM198513 |
02KM255, normal |
GSM198514 |
02PB422, normal |
GSM198515 |
02KM697, normal |
GSM198516 |
01PB943, normal |
GSM198517 |
01PB1072, normal |
GSM198518 |
01PB1096, normal |
GSM198519 |
01KM1171, normal |
GSM198520 |
98KM1251, normal |
GSM198521 |
AML 17 |
GSM198522 |
AML 35 |
GSM198524 |
02KM2732, normal |
GSM198525 |
99PB1321, normal |
GSM198526 |
00PB262, normal |
GSM198527 |
99PB1308, 46,XX |
GSM198528 |
00KM432, 46,XX[20](D|sseldorf) |
GSM198529 |
00KM1797, 46,XX[11] |
GSM198530 |
01KM1517, 46,XX |
GSM198531 |
01KM1396, normal |
GSM198532 |
00KM1316, 46,XY[4] |
GSM198533 |
01PB1806, normal |
GSM198534 |
01PB2118, 46,XY[25] in Gvttingen |
GSM198535 |
02KM2809, 46,XX[9] |
GSM198536 |
03KM2111, 46,XX[11] |
GSM198537 |
01PB1574, normal |
GSM198538 |
98KM585, normal |
GSM198539 |
00KM2459, normal |
GSM198540 |
02KM1746, normal |
GSM198541 |
01KM321, normal |
GSM198542 |
AML 10 |
GSM198543 |
AML 110 |
GSM198544 |
AML 55 |
GSM198546 |
AML 22 |
GSM198547 |
02PB302, 46,XY[20] |
GSM198548 |
00KM2370, 46,XY[18] |
GSM198549 |
03KM25, 46,XY[37] in Kiel |
GSM198550 |
AML 94 |
GSM198551 |
01KM1717, 46,XY[13] |
GSM198552 |
03KM1144, 46,XX[10] |
GSM198553 |
99PB377, 46,XX |
GSM198554 |
03KM894, 46,XX[13] |
GSM198555 |
01PB360, 46,XX[9] |
GSM198556 |
01KM441, 46,XY[12] |
GSM198557 |
00KM856, normal |
GSM198558 |
03KM1301, 46,XX |
GSM198559 |
03PB2769, 46,XX[17] |
GSM198560 |
03KM3217, 46,XX[18] |
GSM198561 |
03KM2384, 46,XX[16] |
GSM198562 |
02PB3311, 46,XY[12] |
GSM198563 |
03KM253, 46,XY[13] |
GSM198564 |
03KM3557, 46,XY[14] |
GSM198565 |
03KM3189, 46,XX[12] |
GSM198566 |
03KM804, 46,XY[18] |
GSM198567 |
03KM2101, 46,XX[12] |
GSM198568 |
02PB3193, 46,XX[11] |
GSM198569 |
AML 30 |
GSM198570 |
03KM2187, 46,XX[10] |
GSM198571 |
02PB3375, 46,XX[15] |
GSM198572 |
AML 64 |
GSM198573 |
02KM2951, 46,XY[15] |
GSM198574 |
02KM3077, 46,XX[10] |
GSM198575 |
01KM2148, normal |
GSM198576 |
AML 12 |
GSM198577 |
01PB694, normal |
GSM198578 |
99KM831, normal |
GSM198579 |
00KM1572, 46,XX [15] |
GSM198580 |
AML 11 |
GSM198581 |
00PB1729, normal |
GSM198582 |
AML 7 |
GSM198583 |
03KM2735, 46,XX[16] |
GSM198584 |
99KM139, 46,XX |
GSM198585 |
98PB199, normal |
GSM198586 |
98PB834, normal |
GSM198587 |
98PB987, normal |
GSM198588 |
98KM1178, normal |
GSM198589 |
99PB311, normal |
GSM198590 |
99KM302, normal |
GSM198591 |
02KM896, normal |
GSM198592 |
99PB992, 46,XX |
GSM198593 |
02KM2188, normal |
GSM198594 |
RNA: 99PB1142, normal |
GSM198595 |
03KM442, 46,XY[12] |
GSM198596 |
99KM208, 46,XX |
GSM198597 |
03PB165, 46,XY[15] |
GSM198598 |
99KM758, 46,XY |
GSM198599 |
99KM279, 46,XX |
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Relations |
BioProject |
PRJNA100863 |
Supplementary data files not provided |
Processed data included within Sample table |
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