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| Status |
Public on Apr 16, 2016 |
| Title |
gene expression profiles in PC9 erlotinib resistance cells after erlotinib, HDAC inhibitor YF454A or combination treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To identify the potential mechanisms of enhanced activity of combined inhibition of erlotinib and YF454A, we conducted a microarray analysis on gene expression profiles in PC9 erlotinib cells.
We used Affymetrix GeneChip® Human Transcriptome Array 2.0 to detail gene expression after indicated treatments and identified the molecular mechanism during this process to facilitate further studies.
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| Overall design |
PC9 erlotinib resistance cells were treated with vehicle control, erlotinib (5 µM), HDAC inhibitor YF454A (0.2 µM), or the combination of erlotinib and YF454A for 12 h. Samples were obtained from three independent biological replicates.RNA from each sample was labeled and hybridized using Affymetrix GeneChip® Human Transcriptome Array 2.0.
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| Contributor(s) |
Chen G, Yu W, Liu M, Pang X |
| Citation(s) |
28749535 |
| |
| Submission date |
Apr 14, 2016 |
| Last update date |
Oct 07, 2019 |
| Contact name |
Xiufeng Pang |
| E-mail(s) |
xfpang@bio.ecnu.edu.cn
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| Phone |
+86-21-24206942
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| Organization name |
East China Normal University
|
| Department |
School of Life Sciences
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| Lab |
Institute of Biomedical Sciences
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| Street address |
500 Dongchuan Road
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| City |
Shanghai |
| ZIP/Postal code |
200241 |
| Country |
China |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA318629 |
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