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| Status |
Public on Sep 08, 2016 |
| Title |
RNA expression analysis of neuroblastoma cell lines treated with epigenetic drugs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on the neuroblastoma transcriptome was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in histone modification and DNA methylation.
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| Overall design |
The neuroblastoma cell lines Be(2)-C and IMR5-75 were treated with DAC and EPZ-6438 in combination or alone. Controls were treated with solvent (DMSO). RNA was isolated and sequenced.
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| Contributor(s) |
Henrich KO, Bender S, Saadati M, Gartlgruber M, Shao C, Herrmann C, Parzonka M, Dreidax D, Fischer M, Duffy DJ, Schmezer P, Plass C, Höfer T, Benner A, Pfister SM, Westermann F |
| Citation(s) |
27635046 |
| |
| Submission date |
Apr 02, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Chunxuan Shao |
| E-mail(s) |
c.shao@Dkfz-Heidelberg.de
|
| Organization name |
German Cancer Research Center
|
| Street address |
Im Neuenheimer Feld 280
|
| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA317239 |
| SRA |
SRP072791 |
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