|
| Status |
Public on Oct 06, 2016 |
| Title |
Pathogenicity of genomic duplications is determined by formation of novel chromatin domains (neo-TADs) (RNA-seq) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Genome-scale methods have identified subchromosomal structures so-called topologically associated domains (TADs) that subdivide the genome into discrete regulatory units, establish with their target genes. By re-engineering human duplications at the SOX9 locus in mice combined with 4C-seq and Capture Hi-C experiments, we show that genomic duplications can result in the formation of novel chromatin domains (neo-TADs) and that this process determines their molecular pathology.
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| |
|
| Overall design |
RNA-seq of embryonic limb buds for WT and mutant animals carrying structural variations at the Sox9/Kcnj locus.
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| |
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| Contributor(s) |
Ibrahim DM, Franke M, Schöpflin R, Heinrich V, Andrey G, Mundlos S |
| Citation(s) |
27706140 |
| |
| Submission date |
Feb 19, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Daniel Murad Ibrahim |
| E-mail(s) |
ibrahim@molgen.mpg.de, daniel.ibrahim@bih-charite.de
|
| Phone |
030 84131516
|
| Organization name |
Berlin Institute of Health
|
| Department |
Center for Regenerative Therapies
|
| Street address |
Augustenburger Platz 1
|
| City |
Berlin |
| State/province |
Berlin |
| ZIP/Postal code |
13353 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (17)
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| This SubSeries is part of SuperSeries: |
| GSE78109 |
Pathogenicity of genomic duplications is determined by formation of novel chromatin domains (neo-TADs) |
|
| Relations |
| BioProject |
PRJNA312623 |
| SRA |
SRP070571 |
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