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Series GSE76926 Query DataSets for GSE76926
Status Public on Mar 30, 2016
Title RNA-seq transcriptonal profiling in partial hepatectomy liver tissues in Arid1a WT and liver specific KO mice.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Arid1a is the subunit of SWI/SNF complex, which was reported to guide SWI/SNF to DNA. Here, we found that loss of Arid1a in the liver results in improved liver regeneration after partial hepatectomy.Genome-wide analysis showed that after hepatectomy,loss of Arid1a reduces the recruitment and activity of E2F4 on target promoters, resulting in expression programs that favor regeneration during injury.RNAseq shows transcriptional profiling in WT and Arid1a LKO livers pre- and post-hepatectomy, which confirmed the E2F4 target genes and cell cycle genes were upregulated after hepatectomy.
Overall design After partial hepatectomy, liver transcriptional profiling in WT and Arid1a liver specific KO mice were generated by RNA-seq analysis.
Contributor(s) Sun X, Xing C, Kanchwala M, Liang H, Zhu H
Citation(s) 27044474
Submission date Jan 15, 2016
Last update date May 15, 2019
Contact name Xuxu Sun
Organization name shanghai jiao tong university
Department school of medicine
Street address 227 south chongqing road
City shanghai
ZIP/Postal code 200025
Country China
Platforms (2)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (10)
GSM2040943 RNAseq_prePHX_WT_rep1
GSM2040944 RNAseq_prePHX_WT_rep2
GSM2040945 RNAseq_prePHX_KO_rep1
This SubSeries is part of SuperSeries:
GSE76935 Suppression of SWI/SNF component Arid1a promotes mammalian regeneration through chromatin remodeling
BioProject PRJNA308950
SRA SRP068517

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE76926_RAW.tar 12.3 Mb (http)(custom) TAR (of XLS)
GSE76926_phx-40h-filtered.merged.genes.fpkm_tracking.txt.gz 704.3 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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