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| Status |
Public on Oct 01, 2007 |
| Title |
Transcriptome analysis of an oxidative stress-induced rat renal carcinogenesis model |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces oxidative renal tubular damage that subsequently leads to renal cell carcinoma in rodents. Here we used gene expression microarrays to find target oncogenes in this model. Network analysis of the gene expression microarray data revealed the involvement of beta-catenin pathway in the induced cancers.
Keywords: dose response, disease state analysis
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| Overall design |
Carcinogenesis protocol was performed using specific pathogen-free male Wistar rats or male F1 hybrid rats between Fischer344 and Brown-Norway strains. A total of 10 microarrays (Rat Genome 230 2.0; 31,999 genes; Affymetrix Inc., Santa Clara, CA) were used for the screening purpose; two for each group of untreated control, Fe-NTA treatment for 1 week, Fe-NTA treatment for 3 weeks, Fe-NTA-induced RCCs with neither peritoneal invasion nor metastasis and Fe-NTA-induced RCCs with pulmonarymetastasis.
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| Contributor(s) |
Toyokuni S, Liu Y, Akatsuka S, Noguchi N, Kodama T |
| Citation(s) |
18055543, 25008760 |
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| Submission date |
Apr 26, 2007 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Shinya Toyokuni |
| E-mail(s) |
akatsuka@med.nagoya-u.ac.jp
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| Organization name |
Nagoya University
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| Department |
Pathology
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| Street address |
65 Tsuruma-Cho, Showa-Ku
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| City |
Nagoya |
| State/province |
Aichi |
| ZIP/Postal code |
466-8550 |
| Country |
Japan |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA100249 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE7625_RAW.tar |
43.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data provided as supplementary file |
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