GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE75851 Query DataSets for GSE75851
Status Public on Oct 04, 2016
Title ILC progenitor CEL-seq
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Here we identify the c-kit+ CILP population which generates all ILC subsets including NK cells, and the CD25- ILC2-restricted Sca-1+ CILP. We mapped the transcriptional changes that occur in ILC progenitor commitment identifying new regulatory factors and provide a map for early ILC differentiation. Finally, we mapped the subsequent transcriptional changes that occur in c-kit+ CILP in absence of Id2 and Tcf7, key regulators downstream of Nfil3.
Overall design 100 cells of each population were purified from wild-type, Id2-/- or TCF7-/- mice. 64 samples were analysed in 2 different experiment. We purified Common innate lymphoid progenitor (CLP), a4b7-expressing CLP, common innate lymphoid progenitor (CILP), Sca1+ CILP, and Group 2 innate lymphoid cell progenitor (ILC2p).
Contributor(s) Seillet C,  Mielke LA, Zalcenstein D, Su S, Gao J, Shi W, Ritchie M, Naik S,  Huntington ND, Carotta S, Belz GT
Citation(s) 27705792
Submission date Dec 09, 2015
Last update date May 15, 2019
Contact name Shian Su
Organization name Walter and Eliza Hall Institute of Medical Research
Department Molecular Medicine
Lab Ritchie Lab
Street address 1G Royal Parade
City Melbourne
State/province Victoria
ZIP/Postal code 3052
Country Australia
Platforms (2)
GPL16417 Illumina MiSeq (Mus musculus)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (70)
GSM1968840 CEL-Seq_1
GSM1968841 CEL-Seq_2
GSM1968842 CEL-Seq_3
BioProject PRJNA305531
SRA SRP067183

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE75851_counts_batch1.txt.gz 349.0 Kb (ftp)(http) TXT
GSE75851_counts_batch2.txt.gz 437.8 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap