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Series GSE75541 Query DataSets for GSE75541
Status Public on Dec 01, 2015
Title Analysis of altered miRNA expression profiles in the genetic hypercalciuric stone-forming (GHS) rat compared to normal SD rat
Platform organism synthetic construct
Sample organism Rattus norvegicus
Experiment type Non-coding RNA profiling by array
Summary Urolithiasis is a common disease to human beings, and idiopathic hypercalciuria (IH) is an important risk factor of calcium urolithiasis, previous studies strongly suggested that the decreased tubular Ca2+ reabsorption played a key role of hypercalciuria. However,the molecular mechanism of IH-urolithiasis formation is still not completely elucidated. GHS rat is regarded as an ideal animal model of calcium urolithiasis, reveals many identical pathophysiologic characteristics with IH patients . We analyzed miRNA expression profiles of the kidney of GHS rat in order to find out the target genes and signaling pathways in the pathogenesis of IH.
Overall design The colony of GHS rats were created by the selective breeding of male and female SD rats with the highest 24 hour urine excretions (doi: 10.3390/ijms160716313). In the 28 generation, GHS rats have stabilized excreted significant higher level of urine calcium than wild-type normal SD rats, and reveals many identical pathophysiologic characteristics with IH patients, such as normal serum Ca2+, hypercalciuria, elevated intestinal Ca2+ resorption and a tendency to lose calcium from the bone. This present study examined the miRNAs expression of three pairs of GHS rats’ kidneys with normal SD rats by microarrays.
Contributor(s) Lu Y, Wang S
Citation(s) 27069814
Submission date Dec 01, 2015
Last update date May 02, 2017
Contact name Yuchao LU
Organization name Tongji Hospital of Tongji medical college, Huazhong University of Science &Technology
Department Urology
Street address 1095# Jiefang Avenue
City Wuhan
State/province Hubei
ZIP/Postal code 430030
Country China
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (6)
GSM1958847 NOR1, biological rep 1
GSM1958848 NOR2, biological rep 2
GSM1958849 NOR3, biological rep 3
This SubSeries is part of SuperSeries:
GSE75543 miRNA and mRNA profiles in the genetic hypercalciuric stone-forming (GHS) rat compared to normal SD rat
BioProject PRJNA304499

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Supplementary file Size Download File type/resource
GSE75541_RAW.tar 4.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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