|
| Status |
Public on Nov 14, 2015 |
| Title |
Expression of human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Nuclear RNA foci are often associated with mis-regulation of RNA processing in repeat expansion diseases. Here we report transcriptomic analysis of mice expressing expanded G4C2 repeats, the most common genetic cause of FTD/ALS. We show that the presence of numerous nuclear G4C2 repeat RNA foci does not cause extensive changes in RNA processing in this model organism.
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| Overall design |
Comparison of the transcriptomic profile of wild-type mice and mice expressing a human C9ORF72 BAC including 500 G4C2 repeats
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| Contributor(s) |
Peters O, Tran H, Sun H, Gao F, Mueller C, Brown R |
| Citation(s) |
26637797 |
| |
| Submission date |
Nov 13, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Helene Tran |
| E-mail(s) |
helene.tran@umassmed.edu
|
| Organization name |
UMASS
|
| Department |
Neurology
|
| Street address |
55 North Lake Avenue
|
| City |
Worcester |
| ZIP/Postal code |
01655 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA302110 |
| SRA |
SRP066149 |
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