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| Status |
Public on Oct 21, 2016 |
| Title |
Hydroxychloroquine inhibits responses to group A streptococcus in peripheral blood mononuclear cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Immune responses to group A streptococcus in humans can lead to the development of acute rheumatic fever and rheumatic heart disease. Immune pathways that are activated by group A streptococcus are potential targets for inhibiting autoimmune responses to group A streptococcus. This experiment tests the impact of the drug hydroxychloroquine on immune responses to group A streptococcus in peripheral blood mononuclear cells
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| Overall design |
Peripheral blood mononuclear cells from three healthy participants were stimulated with rheumatogenic, heat-killed group A streptococcus for 24 hours, MOI 10. The effect of hydroxychloroquine (20 µM) (HCQ) was measured, both alone and in combination with group A streptococcus (GAS).
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| Contributor(s) |
Martin W, Pacini G, Smyth GK |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 21, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Gordon K Smyth |
| E-mail(s) |
smyth@wehi.edu.au
|
| Phone |
(+61 3) 9345 2326
|
| Fax |
(+61 3) 9347 0852
|
| URL |
http://www.wehi.edu.au
|
| Organization name |
Walter and Eliza Hall Institute of Medical Research
|
| Department |
Bioinformatics
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| Lab |
Smyth
|
| Street address |
1G Royal Pde
|
| City |
Parkville |
| State/province |
Vic |
| ZIP/Postal code |
3052 |
| Country |
Australia |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA299596 |
| SRA |
SRP065194 |
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