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Series GSE74198 Query DataSets for GSE74198
Status Public on Jul 15, 2020
Title Next generation sequencing identifies circulating microRNAs in cardiac arrest patients
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary The goal of this study is to identify circulating microRNAs with prognostic value in a large cohort of comatose survivors of out-of-hospital cardiac arrest. We performed RNA-Seq for short RNAs in plasma, collected 48 hours after return of spontaneous circulation, of 50 cardiac arrest patients including 25 good neurological outcome at 6 months (cerebral performance category 1) and 25 poor neurological outcome including death at 6 months (cerebral performance category score 5). The sequencing generated on average 18.5 million reads per sample. After mapping the reads and counting to relevant entries in miRBase 20, we found 236 microRNAs detected in all 50 samples with TPM above or equals to 1. 11 microRNAs were differentially expressed between 2 groups with False Discovery Rate (FDR) < 5%.
Overall design Plasma microRNA profiles of 50 cardiac arrest patients, including 25 good neurological outcome (cerebral performance category score 1, CPC1) and 25 bad neurological outcome (cerebral performance category score 5, CPC5) at 6 months.
Contributor(s) Devaux Y, Salgado-Somoza A, Zhang L
Citation(s) 32575355
Submission date Oct 20, 2015
Last update date Jul 15, 2020
Contact name Yvan Devaux
Organization name LIH
Lab Cardiovascular Research Unit
Street address 120 route d'Arlon
City Luxembourg
ZIP/Postal code 1150
Country Luxembourg
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (50)
GSM1914391 CPC1 rep1
GSM1914392 CPC1 rep2
GSM1914393 CPC1 rep3
BioProject PRJNA299307
SRA SRP065035

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74198_RAW.tar 2.0 Mb (http)(custom) TAR (of TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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