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| Status |
Public on Sep 29, 2015 |
| Title |
Expression data for analysis of genes affected by PAX3-FOXO1 in alveolar rhabdomyosarcoma cell line Rh4 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
PAX3-FOXO1 is a fusion transcription factor characteristic for the majority of alveolar rhabdomyosarcoma tumors. It is the main oncogenic driver and deregulates expression of PAX3 target genes.
The PAX3-FOXO1 target gene signature was determined in the Rh4 alveolar rhabdomyosarcoma cell line.
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| Overall design |
Rh4 cells were transfected with siRNA directed against PAX3-FOXO1 or scrambled control. RNA was isolated from these cells after 24, 48 and 72 h.
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| Contributor(s) |
Schäfer BW, Ebauer M, Wachtel M |
| Citation(s) |
17525748, 27760049 |
| |
| Submission date |
Sep 28, 2015 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Beat Schäfer |
| E-mail(s) |
beat.schafer@kispi.uzh.ch
|
| Phone |
+41446348853
|
| Organization name |
University Childrens Hospital
|
| Department |
Oncology
|
| Street address |
Balgrist Campus Lengghalde 5
|
| City |
Zurich |
| State/province |
ZH |
| ZIP/Postal code |
8008 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (14)
|
| GSM1895828 |
Rh4-sc siRNA transfected for 24h-2 |
| GSM1895829 |
Rh4-sc siRNA transfected for 48h-1 |
| GSM1895830 |
Rh4-sc siRNA transfected for 48h-2 |
| GSM1895831 |
Rh4-sc siRNA transfected for 72h-1 |
| GSM1895832 |
Rh4-sc siRNA transfected for 72h-2 |
| GSM1895833 |
Rh4-PAX3-FOXO1 siRNA transfected for 24h-1 |
| GSM1895834 |
Rh4-PAX3-FOXO1 siRNA transfected for 24h-2 |
| GSM1895835 |
Rh4-PAX3-FOXO1 siRNA transfected for 48h-1 |
| GSM1895836 |
Rh4-PAX3-FOXO1 siRNA transfected for 48h-2 |
| GSM1895837 |
Rh4-PAX3-FOXO1 siRNA transfected for 72h-1 |
| GSM1895838 |
Rh4-PAX3-FOXO1 siRNA transfected for 72h-2 |
|
| Relations |
| BioProject |
PRJNA297143 |
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