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| Status |
Public on Sep 21, 2016 |
| Title |
Circadian regulation of miR-378 mediates circadian controls of cell cycle and metabolism |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To explore the circadian functions of the miRNAs derived from these circadian primary miRNA transcripts, we focused on miR-378 and examined the transcriptome changes in mouse livers upon miR-378 over-expression at two circadian time points, CT10 and CT22. First, we observed a significant over-representation of the circadian oscillating genes affected by miR-378 over-expression. Cell cycle genes are further enriched in the affected circadian oscillating genes, which implied that miR-378 mediates the circadian control of cell cycle. Our examination of circadian regulatory network involving miR-378 suggests that miR-378 mediates the circadian control of cell cycle and metabolism by forming either coherent or incoherent feed-forward loops with circadian TFs.
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| Overall design |
RNA-sequencing of liver tissue from ad-null or ad-378 (miR-378 overexpression) mice at CT10 and CT22 with two biological replicates.
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| Contributor(s) |
Wang H, Yan J |
| Citation(s) |
26898952 |
| |
| Submission date |
Sep 22, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Haifang Wang |
| E-mail(s) |
wanghf810501@gmail.com
|
| Organization name |
PICB
|
| Department |
functional genomics group
|
| Street address |
NO 320, Yueyang Road
|
| City |
ShangHai |
| ZIP/Postal code |
200031 |
| Country |
China |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA296571 |
| SRA |
SRP063970 |
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