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Series GSE72400 Query DataSets for GSE72400
Status Public on Oct 18, 2016
Title naive T cell heterogeneity after neonatal thymectomy
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The generation of new naive T-cells is dependent on thymic output, but in adults the naive T-cell pool is primarily maintained by peripheral proliferation. Naive T-cells have long been regarded as relatively quiescent cells but recently it was shown that IL-8 production is a signatory effector function of naïve T-cells, at least in newborns. With human aging naïve CD4 T-cell numbers decline but it is not clear whether this is accompanied by (functional) differentiation of naïve T-cells and loss of true naivety. Using a unique cohort of children and adolescents who underwent neonatal thymectomy, we demonstrate that the naive CD4 T-cell compartment in healthy humans is functionally heterogeneous and that this functional diversity is lost after neonatal thymectomy. Thymic regeneration later in life resulted in functional restoration of the naïve T-cell compartment. These data shed further light on functional differentiation within the naive T-cell compartment and the importance of the thymus in naive T-cell homeostasis.
Overall design Rna-seq analysis of immune cells derived from healthy controls and thymectomy patients
Contributor(s) Mokry M
Citation(s) 26901814
Submission date Aug 26, 2015
Last update date May 15, 2019
Contact name Michal Mokry
Organization name Wilhelmina Children's Hospital, University Medical Center Utrecht
Street address Lundlaan 6
City Utrecht
ZIP/Postal code 3584 EA
Country Netherlands
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (20)
GSM1861834 HC1MEMneg
GSM1861835 HC1Nneg
GSM1861836 HC1Npos
BioProject PRJNA293969
SRA SRP062865

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE72400_RAW.tar 25.8 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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