GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE71991 Query DataSets for GSE71991
Status Public on Aug 13, 2015
Title Interspecies Comparative Genomics Identifies Optimal Mouse Models of Scleroderma (Tsk1/+)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not delineated. We applied interspecies comparative analysis of genomic data from multiple mouse models of SSc and patients with SSc to determine which animal models best reflect the SSc intrinsic gene expression subsets.
Overall design Gene expression measured in skin from mice with sclerodermatous graft-versus-host disease, bleomycin-induced fibrosis, or Tsk1/+ and Tsk2/+ mice was mapped to human orthologs and compared to SSc skin biopsy-derived gene expression.
Contributor(s) Sargent J, Li Z
Citation(s) 26945694
Submission date Aug 12, 2015
Last update date Jan 12, 2017
Contact name Michael Whitfield
Phone 6036501105
Organization name Geisel School of Medicine at Dartmouth
Department Genetics
Street address 710 Remsen 74 College Street
City Hanover
State/province New Hampshire
ZIP/Postal code 03755
Country USA
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (4)
GSM1849369 Tsk1 transgenic, TSK1_1-1
GSM1849370 Tsk1 transgenic, TSK1_1-2
GSM1849371 Tsk1 transgenic, TSK1_2-1
This SubSeries is part of SuperSeries:
GSE71999 Interspecies Comparative Genomics Identifies Optimal Mouse Models of Scleroderma
BioProject PRJNA292689

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71991_RAW.tar 21.6 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap