|
| Status |
Public on Apr 05, 2016 |
| Title |
Effect of Smyd1 conditional knockout on gene expression in skeletal muscle |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Transcriptome analysis by RNA-seq of tibialis anterior muscle from control and Smyd1 myocyte-specific conditional knockout mice at 6 weeks of age. Smyd1 is a methyltransferase specifically expressed in striated muscle and CD8+ T cells. Smyd1 deficiency resulted in centronuclear myopathy primarily affecting fast-twitch muscle fibers. These results provide insight into how loss of Smyd1 altered transcriptional programs resulting in centronuclear myopathy.
|
| |
|
| Overall design |
6 animals per group (control and Smyd1 conditional knockout)
|
| |
|
| Contributor(s) |
Stewart MD |
| Citation(s) |
26935107 |
| |
| Submission date |
Aug 03, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
M. David Stewart |
| Organization name |
University of Houston
|
| Street address |
4800 Calhoun Rd
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77204-5001 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA291783 |
| SRA |
SRP061950 |
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