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Series GSE71595 Query DataSets for GSE71595
Status Public on Sep 15, 2015
Title RNA-sequencing of cells derived from the site of inflammation of Juvenile Idiopathic Arthritis patients
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Through RNA sequencing of CD4+ Tmemory/effector cells derived from the synovium of JIA patients and healthy controls, we analyzed the JIA gene expression signature. Treatment of autoinflammatory site-derived patient T cells with the BET-inhibitor JQ1 inhibited immune-related super-enhancers and preferentially reduced disease-associated gene expression, including cytokine-related processes.
Overall design RNA-sequencing of CD4+ memory/effector T cells derived from Healthy Controls (HC) and JIA patients upon JQ1 treatment.
Contributor(s) van Loosdregt J, Peeters JG, Vervoort SJ
Citation(s) 26387944
Submission date Jul 31, 2015
Last update date May 15, 2019
Contact name Janneke Peeters
Organization name UMC Utrecht
Street address Heidelberglaan 100
City Utrecht
ZIP/Postal code 3584CX
Country Netherlands
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (14)
GSM1841068 HC_A_min
GSM1841069 HC_A_plus
GSM1841070 HC_B_min
This SubSeries is part of SuperSeries:
GSE71597 Epigenetic profiling and RNA-sequencing of Juvenile Idiopathic Arthritits (JIA) patients
BioProject PRJNA291597
SRA SRP061881

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71595_RAW.tar 7.0 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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