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| Status |
Public on Jul 29, 2017 |
| Title |
Microenvironmental regulation by miRNAs in pancreatic cancer. |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
To demonstrate the role of miRNAs in desmoplastic stroma of pancreatic cancer patients sample, we compared the miRNA expression patterns in tumor, stroma and normal tissue.
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| Overall design |
Total RNA was extracted from formalin fixed paraffin embedded samples from the pancreatic cancer patients samples. The miRNA expression profiling is done on tumor, stroma and normal tissues seperately using miRCURY LNATM microRNA Array 7'th arrays (Exiqon, Denmark). The expression profiles were background corrected and quantile normalized. Filtering of controls and low expressed probes was done. 755 miRNAs were used to demonstarte the role of miRNAs in tumor and stroma interaction and in carcinogenesis.
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| |
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| Contributor(s) |
Sandhu V, Kure E |
| Citation(s) |
26590090 |
| |
| Submission date |
Jul 29, 2015 |
| Last update date |
Jul 11, 2019 |
| Contact name |
Vandana Sandhu |
| E-mail(s) |
vansan@rr-research.no
|
| Organization name |
Radiumhospitalet, Oslo
|
| Department |
Department of Genetics
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| Street address |
Ullernchausseen 70
|
| City |
Oslo |
| State/province |
oslo |
| ZIP/Postal code |
0310 |
| Country |
Norway |
| |
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| Platforms (1) |
| GPL18058 |
Exiqon miRCURY LNA microRNA array, 7th generation [miRBase v18, condensed Probe_ID version] |
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| Samples (88)
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| Relations |
| BioProject |
PRJNA291451 |
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