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Series GSE71522 Query DataSets for GSE71522
Status Public on Aug 11, 2016
Title Affymetrix SNP array data for Ovarian Cancer Samples
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary This study aimed to generate a new panel of comprehensively, genomically characterized high-grade serous ovarian carcinoma (HGSOC) cell line and xenograft models. Multidimensional genomic data were generated and compared between cell lines/xenografts and the tumours they were derived from, indicating the cell lines/xenografts are highly similar to their patient-matched tumours. Cell line/xenograft data were also compared to TCGA ovarian tumours to show the cell lines are good models of clinical HGSOC.
Overall design Affymetrix SNP 6 arrays were performed according to the manufacturer's instructions on genomic DNA extracted from i) tumour cells purified from ovarian tumour ascites, ii) established cell lines, iii) patient derived xenografts, and iv) lymphoblast lines. Evaluation of the similarity in copy number/methylation/gene expression/mutational profiles of cell lines/tumours/xenografts was performed.
Contributor(s) Gazdar AF
Citation(s) 28881577
Submission date Jul 29, 2015
Last update date Nov 27, 2018
Contact name Kelsie L Thu
Organization name BC Cancer Research Centre
Street address 675 West 10th Avenue
City Vancouver
State/province British Columbia
ZIP/Postal code V5Z 1L3
Country Canada
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (51)
GSM1836137 OVCA-CellLine-HCC5006CL_SNP6
GSM1836138 OVCA-Tumour-HCC5006T_SNP6
GSM1836139 OVCA-CellLine-HCC5011CL_SNP6
This SubSeries is part of SuperSeries:
GSE71525 A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas
BioProject PRJNA291448

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71522_RAW.tar 1.4 Gb (http)(custom) TAR (of CEL)
GSE71522_UTSWovca_SNP_Feb2015_AllCopyNumber_transpose.txt.gz 213.9 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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