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Series GSE71322 Query DataSets for GSE71322
Status Public on Jul 25, 2015
Title Placental transcriptomic pattern of murine advanced paternal age model of autism
Organism Mus musculus
Experiment type Expression profiling by array
Summary Advanced paternal age has been shown to be a significant risk factor for neurodevelopmental psychiatric disorders, particularly autism. We have recently shown that mice conceived by old fathers display behavioral abnormalities which resemble key diagnostic symptoms of human autism. De novo mutations and epigenetic alterations increase in the male germ line during ageing and are thought to mediate the effect of paternal age on occurrence of diseases occurrence. Because the placenta carry a predominantly fetal genetic background, age-related mutagenesis and epigenetic errors might negatively influence placental physiology and in turn perturb fetal brain development. Here, we examined the impact of paternal age on placental mRNA transcriptome. This work was supported by Programme FP7-KBBE-2012.1.3-04, GA no. 312097 Acronym: FECUND, to GEP; MIUR/CNR, Programme FIRB. GA n. B81J12002520001 Acronym: GenHome, to PL. This study was also partially financed by the IGAB PAS project (S.III.1.3), Polish Scientific Committee Grant 2011/03/N/NZ29/05222, Polish Ministry of Science and Higher Education Grants N N519 657940 and N N311 604938.
Overall design We compared gene expression patterns of mouse placentas harvested from either advanced paternal age model (APA) of autism or control animals. We included 2 comparisons: 1) placenta of female APA vs placenta of female control; 2) placenta of male APA vs placenta of male control. Each comparison was composed of 3 biological replicates. To minimize family bias, poolings contained at most one placenta per sex from each dam to a minimum of one and a maximum of three placentas per group/sex.
Contributor(s) Goscik J, Stankiewicz AM, Swiergiel AH, Loi P, Modlinski JA, Ptak GE, Sampino S
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Submission date Jul 24, 2015
Last update date Jan 19, 2018
Contact name Adrian Mateusz Stankiewicz
Organization name Institute of Genetics and Animal Breeding of the Polish Academy of Sciences
Department Animal Behaviour
Street address Jastrzebiec, ul. Postepu 36A
City Magdalenka
State/province Mazovia
ZIP/Postal code 05-552
Country Poland
Platforms (1)
GPL10333 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)
Samples (6)
GSM1832631 Female placenta Biol. Rep. 1
GSM1832632 Female placenta Biol. Rep. 2
GSM1832633 Female placenta Biol. Rep. 3
BioProject PRJNA290905

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71322_RAW.tar 98.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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