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| Status |
Public on Jul 02, 2021 |
| Title |
Gene expression of lung tissues in non-human primate (NHP, rhesus macaque) after exposure to thoracic irradiation |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by array
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| Summary |
Radiation-induced lung injury is a serious health threat to victims of radiological incidents or patients receive radiation in the thorax. Studying the gene expression in lung tissues after radiation exposure helps to understand the mechanism of radiation-induced lung injury.
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| Overall design |
Rhesus macaques were exposed to 9.0 to 12.0 Gy whole thoracic lung irradiation (WTLI) and followed for 180 days. Each animal was euthanized when the pre-determined euthanasia criteria were met or past the 180 days. Lung tissues from the euthanized animals were used for gene expression profiling analysis. n=14 in the decedent group, n=12 in the survivor group, and n=5 in the non-irradiated group.
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| Contributor(s) |
Cui W, MacVittie TJ |
| Citation(s) |
34546215 |
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| Submission date |
Jul 15, 2015 |
| Last update date |
Oct 01, 2021 |
| Contact name |
Wanchang Cui |
| Organization name |
University of Maryland Baltimore
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| Department |
Radiation Oncology
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| Lab |
10 South Pine St
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| Street address |
10 South Pine St
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| City |
Baltimore |
| State/province |
Maryland |
| ZIP/Postal code |
21201 |
| Country |
USA |
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| Platforms (1) |
| GPL20695 |
[RheGene-1_1-st] Rhesus Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (31)
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| GSM1823644 |
lung,0 Gy rep 4 |
| GSM1823645 |
lung,0 Gy rep 5 |
| GSM1823646 |
lung,decedent rep 1 |
| GSM1823647 |
lung,decedent rep 2 |
| GSM1823648 |
lung,decedent rep 3 |
| GSM1823649 |
lung,decedent rep 4 |
| GSM1823650 |
lung,decedent rep 5 |
| GSM1823651 |
lung,decedent rep 6 |
| GSM1823652 |
lung,decedent rep 7 |
| GSM1823653 |
lung,decedent rep 8 |
| GSM1823654 |
lung,decedent rep 9 |
| GSM1823655 |
lung,survivor rep 1 |
| GSM1823656 |
lung,survivor rep 2 |
| GSM1823657 |
lung,survivor rep 3 |
| GSM1823658 |
lung,survivor rep 4 |
| GSM1823659 |
lung,decedent rep 10 |
| GSM1823660 |
lung,decedent rep 11 |
| GSM1823661 |
lung,decedent rep 12 |
| GSM1823662 |
lung,decedent rep 13 |
| GSM1823663 |
lung,decedent rep 14 |
| GSM1823664 |
lung,survivor rep 5 |
| GSM1823665 |
lung,survivor rep 6 |
| GSM1823666 |
lung,survivor rep 7 |
| GSM1823667 |
lung,survivor rep 8 |
| GSM1823668 |
lung,survivor rep 9 |
| GSM1823669 |
lung,survivor rep 10 |
| GSM1823670 |
lung,survivor rep 11 |
| GSM1823671 |
lung,survivor rep 12 |
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| Relations |
| BioProject |
PRJNA289999 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE70943_RAW.tar |
143.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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