|
| Status |
Public on Mar 31, 2016 |
| Title |
MiR-26 dampens IL-6 production by down-regulating TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found NF-kB signaling as a major target of miR-26 based on an analysis of the changes in gene activation by TNF-a in response to alteration of miR-26 levels.
|
| |
|
| Overall design |
Transcriptional profiling of genes in response to either a miR-26 mimic or miR-26 antagomir.
|
| |
|
| Contributor(s) |
Chen CA, Chang JT, Ho Y, Shyu A |
| Citation(s) |
27025651 |
| |
| Submission date |
Jul 13, 2015 |
| Last update date |
Jun 22, 2021 |
| Contact name |
Jeffrey Chang |
| E-mail(s) |
jeffrey.t.chang@uth.tmc.edu
|
| Organization name |
University of Texas
|
| Street address |
6431 Fannin St
|
| City |
Houston |
| ZIP/Postal code |
77019 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA289656 |
| SRA |
SRP060719 |
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