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| Status |
Public on Jul 12, 2017 |
| Title |
Regulation of gene expression after FGF2-induced gyrification of mouse brain |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We analyze the cortical transcriptome under physiological or FGF2-perturbed conditions. Using system biology approaches (DGE, WGCNA and kinase enrichment analysis) we identify networks of co-expressed genes involved in neuronal differentiation and cortical patterning that are either up- or down-regulated in vivo after FGF2 perturbation.
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| Overall design |
Total RNA was isolated from dorsal telencephalons of E13.5 embryos, from anterior brain regions (rostral to the hippocampus). A total of 3 FGF-2 injected embryos were analyzed and compared to three age-matched vehicle-injected controls.
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| Contributor(s) |
Simone T, Coppola G, Vaccarino FM |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 13, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Flora Vaccarino |
| Organization name |
Yale University
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| Department |
Child Study Center
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| Lab |
Vaccarino
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| Street address |
230 South Frontage Road
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| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06520 |
| Country |
USA |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA289624 |
| SRA |
SRP060706 |
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