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Series GSE70728 Query DataSets for GSE70728
Status Public on Feb 22, 2016
Title Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence.
Overall design Comparison of gene expression in wild-type and knockout HSPCs
Contributor(s) Tzatsos A, Kai Y
Citation(s) 26808549
Submission date Jul 10, 2015
Last update date May 15, 2019
Contact name Alexandros Tzatsos
Phone 2029949104
Organization name George Washington University
Department GW Cancer Center
Lab Cancer Epigenetics Laboratory
Street address 800 22nd St NW SEH 8850
City Washington
State/province DC
ZIP/Postal code 20052
Country USA
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (4)
GSM1816880 WT-Rep1
GSM1816881 WT-Rep2
GSM1816882 KO-Rep1
This SubSeries is part of SuperSeries:
GSE70729 Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies
BioProject PRJNA289452
SRA SRP060647

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Supplementary file Size Download File type/resource
GSE70728_KDM2B_RNAseq_DEG.diff.gz 758.6 Kb (ftp)(http) DIFF
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