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Series GSE69740 Query DataSets for GSE69740
Status Public on Jun 09, 2018
Title Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a fusion partner independent manner
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Chromosomal rearrangements of the Mixed Lineage Leukemia (MLL) gene result in fusion proteins which retain the N-terminal portion of MLL fused with one of more than 70 different fusion partners. The high diversity of MLL fusion partners raises a question whether it is possible to develop a general therapeutic strategy to block the oncogenic activity of MLL fusion proteins in a fusion partner independent manner. We have demonstrated that blocking the menin-MLL interaction using small molecule inhibitor inhibits oncogenic activity of different MLL fusion proteins according to a mechanism that is independent on the fusion partner.
 
Overall design MLL-AF9, MLL-AF6 and MLL-AF1P transformed cells were treated with the menin-MLL inhibitor MI-2-2
 
Contributor(s) Grembecka J, Cierpicki T, Purohit T, Wang J
Citation(s) 26084867
Submission date Jun 10, 2015
Last update date Apr 14, 2022
Contact name Jingya Wang
E-mail(s) wangjin@medimmune.com
Phone 3013980977
Organization name MedImmune.LLC
Street address 1 Medimmune Way
City Gaithersburg
State/province Maryland
ZIP/Postal code 20878
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (18)
GSM1708052 MLL-AF9_DMSO_rep1
GSM1708053 MLL-AF9_DMSO_rep2
GSM1708054 MLL-AF9_DMSO_rep3
Relations
BioProject PRJNA286308
SRA SRP059329

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69740_RPKM.txt.gz 1.7 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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