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Series GSE69654 Query DataSets for GSE69654
Status Public on Apr 04, 2016
Title Chromosomal deletions linked to p53 loss of heterozygosity promote cancer through p53-independent mechanisms
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The purpose of current study is to identify the differentiated gene expression associated with mouse 11B3 deletion, syntenic to human chromosome 17p13.1. We compared four different mouse acute myeloid leukemia cells, freshly isolated from mouse bone marrows with either 11B3fl/p53fl;shNf1;shMll3;Vav1-Cre or p53fl/fl;shNf1;shMll3;Vav1-Cre. The RNA-seq results indicate that genes located on chromosome 11B3 mostly reduce gene expression level in 11B3 deleted leukemia cells.
Overall design Examination RNA expression level in 11B3-deleted vs p53-loss only samples.
Contributor(s) Lowe SW, Liu Y
Citation(s) 26982726
Submission date Jun 08, 2015
Last update date May 15, 2019
Contact name Yu Liu
Phone 86-18280188730
Organization name Sichuan University
Street address 6 Wangjiang Road
City Chengdu
ZIP/Postal code 610065
Country China
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (8)
GSM1705357 11B3fl/p53fl rep1
GSM1705358 11B3fl/p53fl rep2
GSM1705359 11B3fl/p53fl rep3
BioProject PRJNA286105
SRA SRP059237

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Supplementary file Size Download File type/resource
GSE69654_11B3.xls.gz 1011.2 Kb (ftp)(http) XLS
GSE69654_11B3vsp53.xls.gz 973.8 Kb (ftp)(http) XLS
GSE69654_RAW.tar 1.7 Mb (http)(custom) TAR (of TXT)
GSE69654_p53.xls.gz 1011.4 Kb (ftp)(http) XLS
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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