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Status |
Public on Aug 01, 2015 |
Title |
microRNA expression profiling of human sarcoma cell lines (~68) in the Molecular Pharmacology Branch, DTP, DCTD NCI collection of human cell lines |
Organism |
Homo sapiens |
Experiment type |
Non-coding RNA profiling by array
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Summary |
Characterization of ~68 cell lines derived from human sarcoma and 5 normal counterpart cells, including drug sensitivity testing, gene expression profiling and microRNA expression profiling have been completed. Data and tools for searching these data will be made publicly available through the NCI Developmental Therapeutics Program. The raw data (RCC files) are provided through the GEO website. Sarcoma represents a variety of cancers at arise from cells of mesenchymal origin and have seen limited treatment advances in the last decade. Drug sensitivity data coupled with the transcription and microRNA profiles of a cohort of sarcoma cell lines may help define novel treatment paradigms.
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Overall design |
For each cell line, microRNA expression was measured on nCounter miRNA Expression Arrays (Nanostring Technologies), providing multiplexed, digital detection and counting of 800 human microRNA's.
Please note that there are 2 replicates included in the study: A-204-rep1 and A-204-rep2, ES-4-rep1 and ES-4-rep2 resulting total 77 samples.
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Contributor(s) |
Monks A, Polley E, Teicher B |
Citation(s) |
26351324 |
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Submission date |
Jun 02, 2015 |
Last update date |
Sep 11, 2015 |
Contact name |
Eric C Polley |
E-mail(s) |
eric.polley@nih.gov
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Organization name |
National Cancer Institute
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Department |
Biometric Research Branch
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Street address |
9609 Medical Center Drive, Rm 5W118
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City |
Bethesda |
State/province |
MD |
ZIP/Postal code |
20892 |
Country |
USA |
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Platforms (1) |
GPL20275 |
NanoString nCounter Human miRNA Expression Assay v2 [mRNA ID] |
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Samples (77)
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This SubSeries is part of SuperSeries: |
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Relations |
BioProject |
PRJNA285892 |