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Series GSE69147 Query DataSets for GSE69147
Status Public on Sep 01, 2016
Title Histone genes transcription regulators binding in human cancer (U2OS) and normal (hTERT-RPE1) cells
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The regulation of replication-dependent histone genes by CASP8AP2 and NPAT is likely direct, based on ChIP-seq. CASP8AP2 and NPAT ChIP-Seq peaks were enriched near transcription start sites (TSSs) of replication-dependent, but not replication-independent histone genes on chromosomes 1, 6 and 12 in both cell lines. HINFP ChIP-Seq peaks were enriched near transcription start sites (TSSs) of replication-dependent histone genes H4 and H2B and replication-independent histone genes H1FX and H1F0 in both cell lines. Another histone gene regulator, E2F1 also bound to TSSs of many histone genes mainly replication-independent.
Overall design Examination of histone genes transcroption regulators binding by ChIP-seq in normal and cancer cell lines
Contributor(s) Sokolova M, Turunen M
Citation(s) 27929715
Submission date May 21, 2015
Last update date May 15, 2019
Contact name Maria Sokolova
Organization name University of Helsinki
Department Institute of Biotechnology
Lab Nuclear Actin Lab
Street address Viikinkaari 5
City Helsinki
ZIP/Postal code 00014
Country Finland
Platforms (2)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (12)
GSM1693900 ChIP_E2F1_hTERT-RPE1
This SubSeries is part of SuperSeries:
GSE69149 Histone gene regulation in normal and tumor cells
BioProject PRJNA284642
SRA SRP058604

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69147_RAW.tar 21.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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