GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE69007 Query DataSets for GSE69007
Status Public on Aug 01, 2015
Title Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We found that Dnmt3l-KO donor cells display decreased levels of H3K9me3 and H3K27me3 accumulation, higher level of active histone mark H3K27ac and increased cytoplasmic localization of HDAC1, implicating a permissive epigenetic state beneficial for nuclear reprogramming.
Overall design To investigate the gene expression profiles of MEFs and to find out the potential genes responsible for the improvement of Dnmt3l-KO cloned embryos.
Contributor(s) Liao HF, Mo CF, Wu SC, Cheng DH, Yu CY, Chang KW, Kao TH, Lu CW, Pinskaya M, Morillon A, Lin SS, Cheng WT, Bourchis D, Bestor T, Sung LY, Lin SP
Citation(s) 26159833
Submission date May 18, 2015
Last update date May 15, 2019
Contact name Shau-Ping Lin
Organization name National Taiwan University
Department Institute of Biotechnology
Street address 4F, No. 81, Chang-Xing St.,
City Taipei City
State/province select a state
ZIP/Postal code 106
Country Taiwan
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (4)
GSM1690027 WT-Rep1 (T7)
GSM1690028 Dnmt3l-KO-Rep1 (T8)
GSM1690029 WT-Rep2 (T9)
BioProject PRJNA284278
SRA SRP058459

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69007_DESeq_mouseRNA_fpkm.NCBI_refseq.txt.gz 5.4 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap