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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 01, 2015 |
| Title |
Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We found that Dnmt3l-KO donor cells display decreased levels of H3K9me3 and H3K27me3 accumulation, higher level of active histone mark H3K27ac and increased cytoplasmic localization of HDAC1, implicating a permissive epigenetic state beneficial for nuclear reprogramming.
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| Overall design |
To investigate the gene expression profiles of MEFs and to find out the potential genes responsible for the improvement of Dnmt3l-KO cloned embryos.
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| Contributor(s) |
Liao HF, Mo CF, Wu SC, Cheng DH, Yu CY, Chang KW, Kao TH, Lu CW, Pinskaya M, Morillon A, Lin SS, Cheng WT, Bourchis D, Bestor T, Sung LY, Lin SP |
| Citation(s) |
26159833 |
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| Submission date |
May 18, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Shau-Ping Lin |
| E-mail(s) |
shaupinglin@ntu.edu.tw
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| Organization name |
National Taiwan University
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| Department |
Institute of Biotechnology
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| Street address |
4F, No. 81, Chang-Xing St.,
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| City |
Taipei City |
| State/province |
select a state |
| ZIP/Postal code |
106 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA284278 |
| SRA |
SRP058459 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE69007_DESeq_mouseRNA_fpkm.NCBI_refseq.txt.gz |
5.4 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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