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| Status |
Public on May 31, 2016 |
| Title |
Affymetrix SNP array data from BM-CD138+, obtained from newly diagnosed Multiple Myeloma patients |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
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| Summary |
The iperactivation of self-renewal mechanisms, like Hedgehog (HH) pathway, which govern the refuel of Multiple Myeloma neoplastic clone, is critical to relapse events. The bulk of current knowledge is mainly based on the CD138+ cells molecular characterization, but in the light of the recent evidences, which attributed growing relevance to immature precursor clones, we become aware that multiple myeloma disease heterogeneity have more deepen roots. Here, we report on a high-throughput transcriptome study of gene expression profiles in newly diagnosed MM patients analyzed both in the CD138+ plasmacell fraction and in the CD19+ B cells compartment. Resulted data demonstrated that Hedgehog pathway, and in particular, a 10 HH-genes signature was heterogeneously expressed among MM patients, both in mature plasmacells and also in B cells at transcriptional level. Interestingly, this signature divide patients in two subgroups, and it seems that exists a sort of “ying-yang effect” between mature and immature cell compartments that are tightly regulate in order to express this relevant self-renewal pathway according to their maturation state.
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| Overall design |
Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved diagnostic CD138+ cell fractions obtained from bone marrow samples.
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| Contributor(s) |
Terragna C, Dico FA, Martello M |
| Citation(s) |
35082295 |
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| Submission date |
May 18, 2015 |
| Last update date |
Feb 18, 2022 |
| Contact name |
Carolina Terragna |
| E-mail(s) |
carolina.terragna@unibo.it
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| Organization name |
Institute of Hematology "L.A.Seràgnoli"
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| Department |
Department of Experimental, Diagnostic and Specialty Medicine - DIMES
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| Street address |
Via Massarenti, 9
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| City |
Bologna |
| ZIP/Postal code |
40138 |
| Country |
Italy |
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| Platforms (1) |
| GPL6801 |
[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array |
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| Samples (68)
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| GSM1689827 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #174] |
| GSM1689828 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #429] |
| GSM1689829 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #205] |
| GSM1689830 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #313] |
| GSM1689831 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #64] |
| GSM1689832 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #376] |
| GSM1689833 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #22] |
| GSM1689834 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #201] |
| GSM1689835 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #204] |
| GSM1689836 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #208] |
| GSM1689837 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #402] |
| GSM1689838 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #70] |
| GSM1689839 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #73] |
| GSM1689840 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #407] |
| GSM1689841 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #375] |
| GSM1689842 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #25] |
| GSM1689843 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #342] |
| GSM1689844 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #32] |
| GSM1689845 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #185] |
| GSM1689846 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #71] |
| GSM1689847 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #173] |
| GSM1689848 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #189] |
| GSM1689849 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #431] |
| GSM1689850 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #9] |
| GSM1689851 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #334] |
| GSM1689852 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #127] |
| GSM1689853 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #196] |
| GSM1689854 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #262] |
| GSM1689855 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #98] |
| GSM1689856 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #14] |
| GSM1689857 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #422] |
| GSM1689858 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #175] |
| GSM1689859 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #12] |
| GSM1689860 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #396] |
| GSM1689861 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #477] |
| GSM1689862 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #109] |
| GSM1689863 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #350] |
| GSM1689864 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #23] |
| GSM1689865 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #85] |
| GSM1689866 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #110] |
| GSM1689867 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #116] |
| GSM1689868 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #134] |
| GSM1689869 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #188] |
| GSM1689870 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #199] |
| GSM1689871 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #228] |
| GSM1689872 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #238] |
| GSM1689873 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #246] |
| GSM1689874 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #272] |
| GSM1689875 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #273] |
| GSM1689885 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #277] |
| GSM1689886 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #315] |
| GSM1689887 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #48] |
| GSM1689888 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #111] |
| GSM1689889 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #321] |
| GSM1689890 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #341] |
| GSM1689891 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #359] |
| GSM1689892 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #403] |
| GSM1689893 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #457] |
| GSM1689894 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #11] |
| GSM1689895 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #136] |
| GSM1689896 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #155] |
| GSM1689897 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #278] |
| GSM1689898 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #93] |
| GSM1689899 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #161] |
| GSM1689900 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #261] |
| GSM1689901 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #104] |
| GSM1689902 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #311] |
| GSM1689903 |
Multiple Myeloma patient, diagnosis, rep 1 [MM patient #465] |
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| This SubSeries is part of SuperSeries: |
| GSE69000 |
Hedgehog pathway analysis in both CD138+ and B-cells obtained from newly diagnosed Multiple Myeloma patients |
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| Relations |
| BioProject |
PRJNA284349 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE68999_RAW.tar |
2.7 Gb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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