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| Status |
Public on Feb 01, 2016 |
| Title |
Impact of influenza A on human plasmacytoid dendritic cells (pDC) gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Over 2600 genes were differentially expressed in pDCs exposed to influenza A compared with the controls (no virus). Multiple functional group clusters of genes were impacted, including those involving antiviral responses and also metabolism, such as the glycolysis, oxidative phosphorylation, glucose metabolic process, and positive regulation of macromolecule biosynthesis clusters.
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| |
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| Overall design |
Blood pDCs were purified from 5 human donors, exposed ex vivo for 8 h to either influenza A or no virus, harvested, and RNA was extracted for subsequent DNA microarray analysis.
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| |
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| Contributor(s) |
Bajwa G, Gill MA |
| Citation(s) |
26826244 |
| |
| Submission date |
May 13, 2015 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Michelle Ann Gill |
| Organization name |
University of Texas Southwestern Medical Center
|
| Department |
Pediatrics
|
| Street address |
5323 Harry Hines Blvd
|
| City |
Dallas |
| ZIP/Postal code |
75390 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (10)
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| Relations |
| BioProject |
PRJNA283884 |
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