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Series GSE6808 Query DataSets for GSE6808
Status Public on Jun 30, 2009
Title HRI Protects Erythroid Precursors in iron deficiency and beta-Thalassemia by Maintaining GATA-1 and Fog-1 Expression
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary Heme-regulated eIF2α kinase (HRI) is essential for the survival of erythroid precursors in iron and heme deficiency and it also plays a protective role in red blood cell diseases of erythroid protoporphyria and β-thalassemia. In this study, we demonstrated for the first time the impairment of GATA-1 and Fog-1 expressions in iron deficiency and the impairment of GATA-1 expression in β-thalassemia. Furthermore, HRI is necessary to maintain the GATA-1/Fog-1 induced functions in erythroid differentiation, cell cycle and cell survival by sustaining both expressions of GATA-1 and Fog-1 in iron deficiency and in β-thalassemia.
Keywords: Genetic modification
Overall design Three replicates of gene chip profiling were performed for each condition, Wt+Fe, Wt-Fe, Ko+Fe and Ko-Fe.
Contributor(s) Liu S, Bhattacharya S, Han A, Suragani RN, Zhao W, Fry R, Weiss MJ, Chen J
Citation(s) 18665838
Submission date Jan 19, 2007
Last update date Jan 08, 2019
Contact name Sanchita Bhattacharya
Phone 510-486-6881
Organization name MIT
Street address 1 Cyclotron Rd
City Berkely
State/province CA
ZIP/Postal code 94720
Country USA
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL339 [MOE430A] Affymetrix Mouse Expression 430A Array
Samples (24)
GSM63471 13H_1
GSM63472 13H_2
GSM63473 13H_3
BioProject PRJNA99213

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Supplementary file Size Download File type/resource
GSE6808_RAW.tar 40.8 Mb (http)(custom) TAR (of CEL)

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