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Series GSE67472 Query DataSets for GSE67472
Status Public on Apr 01, 2015
Title Airway epithelial gene expression in asthma versus healthy controls
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Airway epithelial brushings were obtained for microarray analysis by research bronchoscopy in 62 subjects with mild-to-moderate asthma not on inhaled steroids and 43 healthy controls. Asthma subjects were stratified into 2 subgroups, Th2 high and Th2 low asthma, based on their expression of a three-gene signature of Type 2 inflammation: POSTN, SERPINB2, and CLCA1.
 
Overall design Gene expression comparisons were made between: 1. asthmatics and healthy controls, and 2. Th2 high asthma and Th2 Low asthma/Healthy controls. The gene expression alterations most associated with asthma were then used in gene set enrichment analyses and gene signature development to compare this asthma dataset to COPD gene expression datasets.
 
Contributor(s) Christenson SA, Arron JR, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG
Citation(s) 25611785, 33883027
Submission date Mar 31, 2015
Last update date May 06, 2021
Contact name Stephanie A Christenson
Organization name University of California, San Francisco
Department Pulmonary and Critical Care
Street address 513 PARNASSUS AVENUE, HSE1305
City San Francisco
State/province California
ZIP/Postal code 94143
Country USA
 
Platforms (1)
GPL16311 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG 14.0.0]
Samples (105)
GSM1647628 Airway epithelium, asthma sample 01
GSM1647629 Airway epithelium, asthma sample 02
GSM1647630 Airway epithelium, asthma sample 03
Relations
BioProject PRJNA280004

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE67472_RAW.tar 654.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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