|
| Status |
Public on Jul 14, 2015 |
| Title |
Transcription Profiling of Malaria-Naïve and Semi-Immune Colombian Volunteers in a Plasmodium vivax Sporozoite Challenge [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report two clusters in the overall profiles of expression among the samples. At the parasitemia onset, there is a strong interferon response reflected in up-regulation of co-regulated transcripts, while unexpectedly we also see down-regulation of transcripts related to TLR signaling and innate immunity. RNASeq also suggested differential expression of reticulocytes and a subset of T cell function. No obvious difference in the transcriptomes of naïve and semi-immune volunteers was seen, however several hundred genes were up-regulated in naïve individuals.
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| |
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| Overall design |
RNA-seq analysis was performed for 12 individuals (6 each from Buenaventura and Cali) for two of the time points, namely the diagnosis day and baseline (pre-challenge day).
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| |
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| Contributor(s) |
Rojas-Peña ML, Vallejo A, Herrera S, Gibson G, Arévalo-Herrera M |
| Citation(s) |
26244760, 30248353, 29698924 |
| |
| Submission date |
Mar 23, 2015 |
| Last update date |
May 22, 2019 |
| Contact name |
Monica L. Rojas-Peña |
| E-mail(s) |
monica.rojas@gatech.edu
|
| Organization name |
Georgia Institute of Technology
|
| Department |
School of Biology
|
| Lab |
Center for Integrative Genomics (CIG)
|
| Street address |
310 Ferst Dr.
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30332 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (24)
|
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| This SubSeries is part of SuperSeries: |
| GSE67470 |
Transcription Profiling of Malaria-Naïve and Semi-Immune Colombian Volunteers in a Plasmodium vivax Sporozoite Challenge |
|
| Relations |
| BioProject |
PRJNA279199 |
| SRA |
SRP056443 |
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