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Series GSE67117 Query DataSets for GSE67117
Status Public on Jun 30, 2019
Title Identifying signals from the skeletal muscle niche that regulate satellite cell function
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Skeletal muscle is the most common tissue in the body. Its continued maintenance and regeneration throughout life is essential to the function of the organism. Satellite cells are critical to regeneration of the skeletal muscle and strategies to improve function of satellite cells are of great importance. Muscle-resident Fibro-Adipogenic Precursors (FAPs) cells are a critical component of the satellite cell niche and help orchestrate efficient muscle regeneration and potentiate satellite cell differentiation via soluble or secreted factors. Populations with similar phenotype and function to muscle FAPs have been isolated from the skin and white adipose tissue. Interactions between tissue-specific FAP cells and resident stem cells in those tissues might be conserved. Therefore, defining specific factors that mediate the relationship between muscle FAPs and satellite cells would have implications for other organs.
Overall design Use parabiosis as a model to determine if muscle FAPs can enter cross-circulation. Perform RNA sequencing of muscle and lung FAPs to identify transcripts that stimulate satellite cell differentiation
Contributor(s) Wagers A, Manohar R
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Submission date Mar 20, 2015
Last update date Jun 30, 2019
Contact name Paul A Wilson
Organization name GSK
Department Target Sciences
Lab Computational Biology
Street address GlaxoSmithKline Medicine Research Centre
City Stevenage
State/province Hertfordshire
ZIP/Postal code SG1 2NY
Country United Kingdom
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (13)
GSM1639324 FAPLung1
GSM1639325 FAPLung2
GSM1639326 FAPLung3
BioProject PRJNA278988
SRA SRP056384

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Supplementary file Size Download File type/resource
GSE67117_AllCount_Processed.txt.gz 466.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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