|
| Status |
Public on Nov 03, 2015 |
| Title |
Gene expression profiling of histone deacetylase inhibition in epithelioid sarcoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Epithelioid Sarcoma (ES) is a rare neoplasm uniquely comprised of cells exhibiting both mesenchymal and epithelial features. Having propensity for local and distant recurrence, it can pose a diagnostic dilemma secondary to pathologic complexity. Patients have dismal prognosis due to lack of effective therapy. HDAC inhibitors exhibit marked anti-tumor effects in various malignancies. Our studies demonstrate that pan-HDAC inhibitors constitute potentially novel therapeutics versus ES. Human ES cells (VAESBJ, HS-ES, Epi544) were studied in vitro to evaluate the effects of HDACi.
|
| |
|
| Overall design |
Gene array analysis was used to identify the impact of HDACi on ES gene expression in three cell lines.
|
| |
|
| Contributor(s) |
Zhang Y, Creighton C, Lev D, Pollock R, Lopez G |
| Citation(s) |
26396249 |
| |
| Submission date |
Mar 11, 2015 |
| Last update date |
Jan 28, 2016 |
| Contact name |
Chad Creighton |
| E-mail(s) |
creighto@bcm.tmc.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Biostatistics, Ducan Cancer Center
|
| Street address |
One Baylor Plaza, Mail Stop: BCM305
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA277982 |
Less...
More...