NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE66175 Query DataSets for GSE66175
Status Public on Feb 21, 2015
Title Imporatance of substantial weight loss for altering gene expression during intensive cardiovascular lifestyle modification
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The objective of this study was to examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. Substantial weight loss (-15.2+3.8%) in lifestyle participants was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes related to immune function and inflammatory responses involving endothelial activation.
In contrast, participants losing minimal weight (-3.1+2.5%) showed only minor changes in cardiovascular risk factors and markers of inflammation, and no changes in gene expression compared to non-intervention controls after 1 year. Weight loss (>10%) during lifestyle modification is associated with down-regulation of genetic pathways governing interactions between circulating immune cells and the vascular endothelium and may be required to successfully reduce CVD risk.
 
Overall design A prospective nonrandomized trail was conducted over 1 year in participants undergoing intensive lifestyle modification to reverse or stabilize progression of coronary artery disease. Cardiovascular risk factors, inflammatory biomarkers, and gene expression as a function of weight loss were assessed in 89 lifestyle participants and 71 retrospectively matched controls undergoing usual care.
 
Contributor(s) Ellsworth DL, Mamula KA, Blackburn HL, McDyer FA, Jellema GL, van Laar R, Costantino NS, Engler RJ, Vernalis MN
Citation(s) 25960328, 26484175
Submission date Feb 20, 2015
Last update date Jul 29, 2019
Contact name Darrell Ellsworth
E-mail(s) d.ellsworth@wriwindber.org
Organization name Windber Research Institute
Street address 620 Seventh St.
City Windber
State/province PA
ZIP/Postal code 15963
Country USA
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (480)
GSM1123226 Matched Ornish Participant [cv000288 baseline]
GSM1123227 Matched Ornish Participant [cv000288 3month]
GSM1123228 Matched Ornish Participant [cv000288 1year]
Relations
BioProject PRJNA276017

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE66175_RAW.tar 948.8 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap