|
| Status |
Public on Feb 02, 2016 |
| Title |
A study of alterations in DNA epigenetic modifications (5mC and 5hmC) and gene expression influenced by simulated microgravity in human lymphoblastoid cells [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Here, in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3, FBXO17, MAP3K13 and VCL in TK6 cells.
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| |
|
| Overall design |
Examination of RNA-seq with 2 replicates each for 1 cell type
|
| |
|
| Contributor(s) |
Chowdhury B, Wang Z, Seetharam A, Thimmapuram J, Liu Y, Lossie AC, Irudayaraj J |
| Citation(s) |
26820575 |
| |
| Submission date |
Feb 13, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Joseph Irudayaraj |
| E-mail(s) |
josephi@purdue.edu
|
| Phone |
765-494-0388
|
| Organization name |
Purdue University
|
| Department |
Bindley Bioscience Center
|
| Street address |
225 S. University Street
|
| City |
West Lafayette |
| State/province |
IN |
| ZIP/Postal code |
47907 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (4)
|
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| This SubSeries is part of SuperSeries: |
| GSE65944 |
A study of alterations in DNA epigenetic modifications (5mC and 5hmC) and gene expression influenced by simulated microgravity in human lymphoblastoid cells |
|
| Relations |
| BioProject |
PRJNA275452 |
| SRA |
SRP055067 |
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