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| Status |
Public on Jul 03, 2020 |
| Title |
Human junior pilocytic astrocytoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Microglia in the microenvironment of low-grade tumors have been shown to allow and support tumor growth, but the expression profile of these microglia are unknown. To examine the role of microglia in junior pilocytic astrocytomas, macrophages were flow sorted from cyroprotected surgical excisions of tumors and normal brain tissues. Upregulated markers of tumor-associated microglia were verified and compared to mouse tumor-associated microglia.
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| Overall design |
Junior pilocytic astrocytoma macrophages were flow sorted. Upregulated genes of glioma associated microglia were verified and further examined.
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| Contributor(s) |
Pong WW, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Bittner P, Leonard JR, Mardis ER, Gutmann DH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 11, 2015 |
| Last update date |
Jul 03, 2020 |
| Contact name |
Winnie W Pong |
| Organization name |
Washington University School of Medicine
|
| Department |
Department of Neurology
|
| Lab |
David H Gutmann Laboratory
|
| Street address |
660 S. Euclid Avenue
|
| City |
St Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL15520 |
Illumina MiSeq (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA275391 |
| SRA |
SRP055012 |
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