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| Status |
Public on Dec 01, 2015 |
| Title |
Combining ChIP-Seq and RNA-Seq data in early placental development to study trophoblast invasion [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The placenta is an understudied organ that has a critical role in mammalian development. In early placental development, the essential process of trophoblast invasion establishes adequate blood flow between mother and fetus. Despite its importance, little is known about the genomic regions responsible for regulating trophoblast invasion. In order to identify enhancers that are important for regulating the process, we carried out ChIP-Seq for an enhancer-associated mark at two time points during early placental development. Combining these data with RNA-Seq data and protein interaction data allowed us to construct a gene-enhancer network describing trophoblast invasion.
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| Overall design |
RNA-Seq at two time points in early placenta development (e7.5 an e9.5). There are 3 biological replicates per time point. Samples were pooled and sequenced on two lanes.
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| |
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| Contributor(s) |
Tuteja G |
| Citation(s) |
26604129 |
| |
| Submission date |
Feb 10, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Geetu Tuteja |
| Organization name |
Iowa State University
|
| Department |
Genetics, Development and Cell Biology
|
| Street address |
2106 Molecular Biology Building
|
| City |
Ames |
| State/province |
IA |
| ZIP/Postal code |
50011 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE65809 |
Combining ChIP-Seq and RNA-Seq data in early placental development to study trophoblast invasion |
|
| Relations |
| BioProject |
PRJNA275121 |
| SRA |
SRP053433 |
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